10/11/86: Sigourney Weaver / (no musical guest)
10/18/86: Malcolm-Jamal Warner / Run DMC
11/8/86: Rosanna Arquette / Ric Ocasek
11/15/86: Sam Kinison / Lou Reed
11/22/86: Robin Williams / Paul Simon with Ladysmith Black Mambazo
12/6/86: Chevy Chase, Steve Martin, and Martin Short / Randy Newman
12/13/86: Steve Guttenberg / The Pretenders
12/20/86: William Shatner / Lone Justice
1/24/87: Joe Montana and Walter Payton / Debbie Harry
1/31/87: Paul Shaffer / Bruce Hornsby & The Range
2/14/87: Bronson Pinchot / Paul Young
2/28/87: Valerie Bertinelli / The Robert Cray Band
3/21/87: Bill Murray / Percy Sledge
3/28/87: Charlton Heston / Wynton Marsalis
4/11/87: John Lithgow / Anita Baker
4/18/87: John Larroquette / Timbuk 3
5/9/87: Mark Harmon / Suzanne Vega